Freyberg Laboratory
Investigating molecular mechanisms of neurotransmitter release and their contribution to neuropsychiatric illnesses
Dopamine Neurotransmission
Synaptic vesicle mechanisms in health and disease
Examining presynaptic dopaminergic neurotransmission using genetic, pharmacological, and imaging approaches in mouse and Drosophila models.
Metabolic Regulation
Dopamine's role beyond the brain
Investigating dopamine's role in pancreatic hormone release and the metabolic effects of antipsychotic medications.
Advanced Imaging
Cutting-edge microscopy techniques
Using in situ cryo-electron microscopy and super-resolution imaging to study vesicle trafficking and synaptic plasticity.
Zachary Z. Freyberg, MD, PhD
Associate Professor of Psychiatry and Cell Biology
Dr. Freyberg leads a multidisciplinary research program investigating fundamental mechanisms of neurotransmitter release and their implications for neuropsychiatric disorders. His work spans from molecular mechanisms to therapeutic applications.